段广有

段广有

个人简介

段广有，教授，副院长，自2016年9月起任职于亚虎娱乐登录中心，目前担任亚虎娱乐登录中心山东省首批优势学科人才团队学术带头人，同时兼任亚虎娱乐登录中心欧美同学会（留学人员联谊会）副秘书长等职。

段博士学术专业为生物信息学，于2014年初获得德国马克思普朗克研究所（分子植物生理所，MPIMP）生物信息学博士学位，之后在欧洲分子生物学实验室（EMBL）从事博士后研究工作，已从事生物信息学相关研发工作十余年；段博士的研究目标是利用生物学、计算机、数学、统计学等交叉学科方法解决生物、农学或者医学等相关问题，已在Nucleic Acids Research, PLoS Computational Biology, Plant Cell, Scientific Reports等国际刊物上发表多篇论文，并且担任BMC Bioinformatics，Journal of Plant Pathology and Microbiology等学术杂志的审稿人。主讲生物信息学、图论等课程。

研究方向

1.系统生物学

2. 结构生物信息学

主持和参与课题

1.山东省高等学校优势学科人才团队培育计划（生物质品种改良团队）(鲁教人字【2015】18号)，山东省教育厅、山东省财政厅，主持，2015年11月~2020年11月，600万；

2.胸腺上皮细胞中异位基因表达的DNA甲基化调控机制研究（31700787），国家自然科学基金委，参与，2018年1月~2020年12月，24万。

发表论文

1.Li, Xin, Guangyou Duan, Wei Zhang, Jinsong Shi, Jiayuan Chen, Shunmei Chen, Shan Gao, and Jishou Ruan. A Furin Cleavage Site Was Discovered in the S Protein of the 201 9 Novel Coronavirus. Chinese Journal of Bioinformatics 2020.

2.Gao, Li, Yong Jie Yang, En Qi Li,Guang You Duan, Xiang Dong Li, Jia Ning Mao, Dong Yan Zhang, and Ye Li. Sgne Expression Profiling of Peripheral Blood Mononuclear Cells in Young Male Trampolinists.Acta Medica Mediterranea2019. 35(5):2693–2701.

3.Heyneke, Elmien, Mutsumi Watanabe, Alexander Erban,Guangyou Duan, Peter Buchner, Dirk Walther, Joachim Kopka, Malcolm John Hawkesford, and Rainer Hoefgen. Effect of Senescence Phenotypes and Nitrate Availability on Wheat Leaf Metabolome during Grain Filling.Agronomy2019. 9(6).

4.Feng Cui, Na Sui,Guangyou Duan, Yiyang Liu, Yan Han, Shanshan Liu, Shubo Wan, and Guowei Li. Identification of metabolites and transcripts involved in salt stress and recovery in peanut.Frontiers in Plant Science2018, 9: 217

5.Shaochuan Shi,Guangyou Duan^#, Dandan Li, Jie Wu, Xintong Liu, Bo Hong, Mingfang Yi, and Zhao Zhang. Two-dimensional analysis provides molecular insight into flower scent ofLilium ‘Siberia’.Scientific Reports2018. 8 (1): 5352

6.Sukackaite, Rasa, Daniela Cornacchia, Malene Ringkjøbing Jensen, Philippe J Mas, Martin Blackledge, Elin Enervald,Guangyou Duan, Tania Auchynnikava, Maja Köhn, Darren J Hart, Sara B C Buonomo. Mouse Rif1 Is a Regulatory Subunit of Protein Phosphatase 1 (PP1).Scientific Reports2017, 7 (1): 2119

7.Hoeger, Birgit, Pablo Rios, Anna Berteotti, Bernhard Hoermann,Guangyou Duan, and Maja Köhn. Mutational Analysis of a Conserved Glutamate Reveals Unique Mechanistic and Structural Features of the Phosphatase PRL-3.ACS Omega2017. 2(12):9171–80.

8.Heyneke, Elmien, Mutsumi Watanabe, Alexander Erban,Guangyou Duan, Peter Buchner, Dirk Walther, Joachim Kopka, Malcolm J. Hawkesford, and Rainer Hoefgen. Characterization of the Wheat Leaf Metabolome during Grain Filling and under Varied N-Supply.Frontiers in Plant Science2017. 8:2048.

9.Karolina Pavic,Guangyou Duan, Maja Koehn. VHR/DUSP3 phosphatase: structure, function and regulation.The FEBS Journal2015, 282(10):1871-1890

10.Guangyou Duan, Dirk Walther. The roles of post-translational modifications in the context of protein interaction networks.PLoS Computational Biology2015, 11(2):e1004049

11.Guangyou Duan, Dirk Walther. Computational phosphorylation network reconstruction: methods and resources.Methods in Molecular Biology2015, 1306: 177-94

12.Guangyou Duan^#, Xun Li, Maja Koehn. The human DEPhOsphorylation database DEPOD: a 2015 update.Nucleic Acids Research2015, 43: D531-D535

13.Ning Zhang, Shan Gao,Guangyou Duan, Yuanming Feng, Jishou Ruan, Tao Zhang. SRD: a universal software tool for DNA/Protein sequence relationship visualization based on undirected graphs.Current Bioinformatics2015, 10: 69-78

14.Guangyou Duan^*. Systems Biology-Based Study for Plant and Phytopathogen Interaction.Plant Pathology & Microbiology2014, 4:e106

15.Umesh Prasad Yadav, Alexander Ivakov, Regina Feil,Guang You Duan, Dirk Walther, Patrick Giavalisco, Maria Piques, Petronia Carillo, Hans-Michael Hubberten, Mark Stitt, John Edward Lunn. The sucrose-Tre6P nexus: specificity and mechanisms of sucrose signalling by trehalose 6-phosphate.Journal of Experimental Botany2014,65(4):1051-68.

16.Guangyou Duan^*, Dirk Walther, Waltraud Schulze. Reconstruction and analysis of nutrient-induced phosphorylation networks in Arabidopsis thaliana.Frontiers in Plant Science2013, 4: 540.

17.Ning Shao,Guang You Duan, Ralph Bock. A New Mediator of Singlet Oxygen Responses in Chlamydomonas and Arabidopsis Identified by a Luciferase-based Genetic Screen in Algal Cells.Plant Cell2013, 25(10): 4209-26.

18.Guangyou Duan^#, Christian Nils, Schwachtje Jens, Walther Dirk, Ebenhöh Oliver. The Metabolic Interplay between Plants and Phytopathogens.Metabolites 2013, 3 (1): 1-23.

19.Gao, Shan, Ning Zhang, Lei Zhang,Guang You Duan, and Tao Zhang. [The Human Variome Project and Its Progress].Yi Chuan = Hereditas / Zhongguo Yi Chuan Xue Hui Bian Ji2010. 32(11):1105–13.

20.Ning Zhang,Guangyou Duan, Shan Gao, Jishou Ruan, Tao Zhang. Prediction of the Parallel / Antiparallel Orientation of Beta-Strands Using Amino Acid Pairing Preferences and Support Vector Machines.Journal of Theoretical Biology2010, 263 (3): 360-8.

21.Shan Gao, Ning Zhang,Guang You Duan, Zhuo Yang, Ji Shou Ruan and Tao Zhang: Prediction of Function Changes Associated With Single Point Protein Mutations Using Support Vector Machines (SVMs).Human Mutation2009, 30 (8):1161-6.

22.Ning Zhang, Jishou Ruan,Guangyou Duan, Shan Gao and Tao Zhang: The interstrand amino acid pairs play a significant role in determining the parallel or antiparallel orientation of β-strands.Biochemical and Biophsical Research Communications2009, 386 (3): 537-543.